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Treatment of Congenital Pseudarthrosis of the Tibia with Recombinant Human Bone Morphogenetic Protein-7 (rhBMP-7)A Report of Five Cases
Francis Young-In Lee, MD, PhD1; Stefano M. Sinicropi, MD1; Fred Suin Lee, MD3; Michael G. Vitale, MD1; David P. RoyeJr., MD1; In Ho Choi, MD, PhD2
1 Department of Orthopaedic Surgery, Center for Orthopaedic Research, Columbia University, 622 West 168th Street, BHN 816, New York, NY 10032. E-mail address for F.Y.-I. Lee: fl127@columbia.edu
3 1608 Lemoine Avenue, Fort Lee, NJ 07024
2 Department of Orthopaedic Surgery, Seoul National University Hospital, 28 Yongon-dong Chongno-gu, Seoul, Korea 110-744
View Disclosures and Other Information
The authors did not receive grants or outside funding in support of their research for or preparation of this manuscript. They did not receive payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, educational institution, or other charitable or nonprofit organization with which the authors are affiliated or associated.
Investigation performed at the Department of Orthopaedic Surgery, Children's Hospital of New York, Columbia University, New York, NY

The Journal of Bone and Joint Surgery, Incorporated
J Bone Joint Surg Am, 2006 Mar 01;88(3):627-633. doi: 10.2106/JBJS.D.02201
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Congenital pseudarthrosis of the tibia is one of the most frustrating conditions encountered in pediatric orthopaedics because of the difficulty in achieving healing. Numerous treatment options have been explored with varying degrees of success1-19. Although some reports have demonstrated successful healing7,9,19, it is very difficult to restore the normal structural and functional integrity of the bone such as that which occurs after treatment of other types of fractures in children4,10,16.
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