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Secondary Chondrosarcoma of the Proximal Part of the Humerus Arising in a Four-Year-Old Boy with Ollier DiseaseA Case Report
Koichi Ogura, MD1; Ken Takeda, MD, PhD1; Tomohiro Fujiwara, MD1; Akihiko Yoshida, MD, PhD1; Hirokazu Chuman, MD1; Akira Kawai, MD, PhD1
1 Departments of Musculoskeletal Oncology (K.O., K.T., T.F., H.C., and A.K.) and Pathology (A.Y.), National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. E-mail address for K. Ogura: ogura-tky@umin.ac.jp. E-mail address for K. Takeda: kentakeda@gmail.com. E-mail address for T. Fujiwara: tomomedvn@gmail.com. E-mail address for A. Yoshida: akyoshid@ncc.go.jp. E-mail address for H. Chuman: hchuuman@ncc.go.jp. E-mail address for A. Kawai: akawai@ncc.go.jp
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Investigation performed at the Departments of Musculoskeletal Oncology and Pathology, National Cancer Center Hospital, Tokyo, Japan

This work was supported in part by a Grant-in-Aid for Scientific Research from the Japanese Ministry of Education, Culture, Sports, Science and Technology (B13314321 for A. Kawai).

Disclosure: One or more of the authors received payments or services, either directly or indirectly (i.e., via his or her institution), from a third party in support of an aspect of this work. None of the authors, or their institution(s), have had any financial relationship, in the thirty-six months prior to submission of this work, with any entity in the biomedical arena that could be perceived to influence or have the potential to influence what is written in this work. Also, no author has had any other relationships, or has engaged in any other activities, that could be perceived to influence or have the potential to influence what is written in this work. The complete Disclosures of Potential Conflicts of Interest submitted by authors are always provided with the online version of the article.

Copyright © 2013 by The Journal of Bone and Joint Surgery, Inc.
JBJS Case Connector, 2013 Dec 24;3(4):1-6. doi: 10.2106/JBJS.CC.M.00156
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Chondrosarcomas are the second most common primary malignant bone tumors; they usually affect older individuals, with a peak incidence in the fourth to sixth decades of life1. They can be classified as primary or secondary, according to origin. Primary chondrosarcoma arises de novo in normal bones, whereas secondary chondrosarcoma arises from preexisting benign lesions such as osteochondroma, or enchondroma in Ollier disease and Maffucci syndrome. Secondary chondrosarcomas are rarely encountered, accounting for approximately 8% to 20% of all chondrosarcomas2-4. Although secondary chondrosarcoma affects younger individuals more frequently than primary chondrosarcoma, to our knowledge, its occurrence in children younger than ten years of age has not been documented previously. We report the case of secondary chondrosarcoma in a young boy with Ollier disease.
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