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Atrial Myxoma with Disseminated Osteolytic Embolic LesionsA Case Report
Chandhanarat Chandhanayingyong, MD1; Scott A. Thompson, MD1; Fabrizio Remotti, MD2; Francis Young-In Lee, MD, PhD1
1 Department of Orthopaedic Surgery, College of Physicians and Surgeons, Columbia University, 650 West 168th Street, Rm 1412, New York, NY 10032. E-mail address for C. Chandhanayingyong: cc3391@columbia.edu. E-mail address for S.A. Thompson: scott.a.j.thompson@gmail.com. E-mail address for F.Y.-I. Lee: fl127@columbia.edu
2 Department of Pathology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, Vanderbilt Clinic 14-215, New York, NY 10032. E-mail address: fr116@columbia.edu
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Disclosure: None of the authors received payments or services, either directly or indirectly (i.e., via his or her institution), from a third party in support of any aspect of this work. None of the authors, or their institution(s), have had any financial relationship, in the thirty-six months prior to submission of this work, with any entity in the biomedical arena that could be perceived to influence or have the potential to influence what is written in this work. Also, no author has had any other relationships, or has engaged in any other activities, that could be perceived to influence or have the potential to influence what is written in this work. The complete Disclosures of Potential Conflicts of Interest submitted by authors are always provided with the online version of the article.

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Investigation performed at the Departments of Orthopaedic Surgery and Pathology, College of Physicians and Surgeons, Columbia University, New York, NY

JBJS Case Connector, 2012 Aug 08;2(3):e36 1-5. doi: 10.2106/JBJS.CC.L.00012
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Cardiac myxoma is a benign neoplasm of endocardial origin. The majority of cases originate in the left atrium near the fossa ovalis1. Presenting symptoms typically include a triad of tumor embolism, blood flow obstruction, and constitutional symptoms2-6. We present a case of left atrial myxoma with cerebral embolism and numerous symptomatic osteolytic lesions involving the pelvis, sacrum, humeri, femora, and multiple vertebrae. The clinical data, including a high serum level of interleukin-6 (IL-6) and discordant results between a technetium-99 (99mTc) bone scan and a 2-deoxy-2-[18 F]fluoro-D-glucose positron emission tomography (18FDG-PET) scan are discussed. At nine years of clinical follow-up, the patient was walking well without neurologic deficits.
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